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However, one puzzling feature of this initial work is that the binding affinity for Ni II and Co II ions are in the low micromolar range, 224 which is significantly less sensitive than the corresponding Ni II - and Co II -sensing metalloregulatory proteins that have affinities in the (sub)-nanomolar range of bioavailable metal (Figure 8A)

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242 When GLP-1 binds to GLP-1R on δ-cells, it activates these cells and promotes the secretion of somatostatin